Abstract: BACKGROUND ＆ AIM:To study clinical significance of immune function variation in the patients with esophageal carcinoma and precancerous lesions.MATERIAL AND METHODS: The complement activities and erythrocyte CR1 adherence function were measured in 60 esophageal patients and 75 precancerous lesions by using trace fast plate complement activity assay and complement activating yeast rosette test,respectively.RESULTS:The average activities of complement were 39.8(13.7～115.3),29.5(11.1～78.5) and 41.5(12.2～138.1) 0respectively in esophageal cancer group and in the groups of atypical hyperplasia I and II phase. The activities of these groups were much higher than that of the health control group. 16.2(7.7～34.1)(P<0.01).Erythrocyte CR1 adherence activity of esophageal carcinoma group was (18.9±5.8)％ and other two precancerous lesions groups were (23.6±3.8)％ and (21.3±4.5)％. These activities were much lower than that of the health control group.(27.2±6.9)％(P<0.001). CONCLUSION: There are different variances in the complement activity and erythrocyte immune adherencefunction have changed significantly in the patients with esophageal carcinoma and precancerous lesions and relative to the lesion phase.It may be to help to diagnose or monitor lesion in early stage.

Key words: esophageal, precancerous lesion, complement, erythrocyte immune